Laughing Gas: The Highs and Lows of Nitrous Oxide Use

Nitrous oxide – better known as “laughing gas” – might sound harmless and fun. In a recreational context, users inhale this colorless gas (often from whipped cream canisters or “whippets”) for a brief, euphoric high that fades within minutes (cdc.gov). It’s cheap, easy to get at stores, and currently legal, which has made it increasingly popular among young people (cdc.gov). In fact, recent reports warn of a surge in use: for example, Michigan saw a 533% jump in nitrous-related poison center calls from 2019 to 2024 (michigan.gov). Most recreational users are teens and adults in their 20s, drawn by the fast buzz and low cost.

Neurological Risks of Heavy Use

Despite the lighthearted nickname, heavy or repeated nitrous oxide use can carry serious neurological risks. The gas inactivates vitamin B₁₂ in the body, and chronic use leads to a functional B₁₂ deficiency that damages nerve cells (cdc.gov). Medical reports have linked frequent use to nerve demyelination (loss of the protective coating on nerves) and even subacute combined degeneration of the spinal cord – a condition that can cause numbness, weakness, and mobility problems (cdc.gov). In other words, what starts as a short-lived high can, in extreme cases, lead to lasting nerve damage. Doctors note that recovery from nitrous-related nerve injury can be slow and sometimes incomplete (cdc.gov), underscoring the importance of moderation and monitoring for symptoms like tingling or weakness.

Lion’s Mane Mushroom and Nerve Recovery

As awareness grows of nitrous oxide’s nerve risks, some users look for ways to support their nervous system after heavy use. One intriguing option in the wellness community is Lion’s Mane mushroom (scientific name Hericium erinaceus), a fungus touted for potential neuroregenerative benefits. Early scientific studies show that compounds in lion’s mane can stimulate nerve growth factor (NGF) release and protect neurons (pmc.ncbi.nlm.nih.gov). In fact, a recent study identified an active compound from lion’s mane that enhanced nerve growth and even improved memory in lab experiments (news-medical.net). While it’s no magic cure for nerve damage, taking lion’s mane extract as an aftercare supplement has some scientific support for promoting nerve health. Experts emphasize that more research is needed, but this mushroom’s neuroprotective properties make it a promising addition to recovery routines – alongside, of course, proper medical treatment and vitamin B₁₂ replenishment for those affected by nitrous oxide misuse.

Sources: CDC MMWR (2023); Michigan Dept. of Health (2025); Int. J. Environ. Res. Public Health (2022); J. Neurochemistry (2023)